Protein mutation sandbox

mewtate

Explore how amino acid substitutions change protein properties using sequence comparison and mutation scoring.

Analyze

Compare proteins

Quick analysis

Compares the two sequences directly. Uses custom aligned FASTA if provided, but does not search for homologs or fetch UniProt functional regions.

Deep analysis

Finds homologs, builds an MSA, identifies the likely protein, fetches UniProt functional regions, then analyzes conservation and functional impact. This can take a minute or two.

Runs the full homolog, conservation, and functional-region workflow.